bActivate
Mare assessment

Is my mare a candidate
for bActivate?

Answer 7 questions about your mare. The assessment takes about 2 minutes and gives you a personalised risk profile based on the clinical criteria used by veterinarians. If her record reads bred three or four cycles, flushed after breeding, oxytocin, Regumate, culture and cytology clean, and still not in foal, this page is for her.

Question 1 of 7 0%

How old is your mare?

Age is the strongest single predictor of dormant uterine infection.

How many foals has she had?

Each pregnancy reduces uterine defense capacity over time.

Has she had an abortion or pregnancy loss?

Including early embryonic death or loss before day 50.

Has she been diagnosed with endometritis?

Any previous episode, treated or untreated.

How many cycles has she failed to conceive?

Counting from when you first started trying this season or across seasons.

What have her endometrial swabs shown?

Standard culture and cytology from cytobrush or low-volume lavage.

Has she had uterine fluid on ultrasound?

Fluid detected post-breeding or during estrus on rectal ultrasound.

Example profiles

14-year-old, 4 foals, clean swabs, 3 failed cycles
2 risk factors (age 12+, 3+ foals) → HIGH RISK: two risk factors. In the Kildangan series (average age 12.7 years) 84% were activation-positive. bActivate strongly indicated.
10-year-old, 2 foals, prior endometritis, clean swab
1 risk factor (endometritis history) → HIGH RISK: clean swab does not rule out infection. bActivate indicated.
12-year-old, 3 foals, abortion 2022, uterine fluid on scan
3 risk factors → HIGH RISK: very high probability. bActivate strongly indicated before next breeding cycle.
8-year-old maiden, no prior issues, 2 failed cycles
0 risk factors → Standard risk. After 2+ failed cycles with clean swabs, bActivate should be discussed with your veterinarian.

Continue reading

The 5-step bActivate protocol
What happens at each stage
Clinical results
83% pregnancy rate in 64 problem mares at Hagyard
Glossary
Dormant persister cell, biofilm, high-risk mare and more
Order bActivate
Available through veterinary distributors worldwide

FAQ

Frequently Asked Questions

Common questions about problem mares, biofilm infections and bActivate activation.

My mare has a clean swab but keeps coming back into season. Is she a candidate?

Yes, possibly. Standard endometrial swab cultures detect only approximately 34% of infections when one is present. If your mare has one or more risk factors (age 12+, 3+ foals, abortion history, prior endometritis) and has failed to conceive for two or more consecutive cycles, bActivate is strongly indicated even with clean swabs.

Is a mare with a history of endometritis a candidate for bActivate?

Yes. A history of endometritis is one of the four primary risk factors. Mares treated for endometritis in the past are at high risk of carrying a dormant persister-state Streptococcus zooepidemicus infection that standard swabs cannot identify and antibiotics cannot reach.

Can a young maiden mare be a candidate for bActivate?

Yes, though probability of dormant infection is lower than in high-risk mares. If a maiden mare has failed to conceive for two or more consecutive cycles with negative swabs and a fertile stallion, bActivate should be discussed with your veterinarian.